It was crazy because Id never been in a place like that in my life where I worked so hard, ate so healthy and could never get down to where I needed to be at, she recalled
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These findings suggest that, when evaluating the effects of amino acid-related metabolic axes, such as Gln-KG, on macrophage polarization, the key is not to simply classify them as pro-inflammatory or anti-inflammatory, but rather to focus on their integrated effects on anaplerotic flux, the spectrum of signaling metabolites, and the supply of epigenetic substrates, thereby reshaping inflammatory thresholds and reparative capacity across different timescales ( Nutrient-sensing pathways provide important clues for explaining the discrepant findings among different studies
Obesity 31 , 17871797 (2023)