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Consent for publication The authors confirm that they obtained written consent from each patient to publish the findings
A daily supplement of 2,500-5,000 mcg of biotin is generally safe, but there is a critical caveat that every patient and prescriber should know about
During an IR state mitochondrial oxidative phosphorylation is suppressed (because of mitochondrial dysfunction and/or reduced mitochondrial content)
Concerns include early treatment adjustment effects, individual sensitivity, and overlapping metabolic or psychological factors
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