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The individual amino acids are absorbed and can be used to resynthesize glutathione intracellularly, but this is a slow, rate-limited process that does not produce the acute plasma elevation seen with parenteral routes
The mechanism is well-characterized at the biochemical level: GSH inhibits tyrosinase, the rate-limiting enzyme in melanin biosynthesis, by binding to its copper-containing active site
In a later study of small numbers of rats studied for 10 weeks, exenatide increased inflammatory cell infiltrate with interstitial edema and fibrosis in 5 of 15 rats (122)
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