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Before approving a new drug, the FDA typically requires companies to conduct a type of study called a randomized controlled trial, in which study participants are allocated by chance to groups that either receive the drug, or are administered a placebo

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Faith JJ, Hayete B, Thaden JT, Mogno I, Wierzbowski J, Cottarel G, Kasif S, Collins JJ, Gardner TS: Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles