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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

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IGF-1 stands for Insulin-like Growth Factor-1 , also known as Somatomedin C, is a hormone produced primarily in the liver, which shares a similar chemical structure to insulin

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