They work by activating GLP1 receptors in the body to increase insulin release from the pancreatic beta-cells, decrease the breakdown of glucose stores from the liver, and slow gastric emptying.[6,8,10,11] Additionally, semaglutide can affect appetite and caloric intake by involving different pathways in the brain.[11] Safety Information The side effects between dulaglutide and semaglutide are similar.[6,8,10,11] The most common side effects seen in patients taking either medication are nausea, diarrhea, vomiting, and abdominal pain
According to the Endocrine Society, Semaglutide has the ability to reduce the risk of heart disease, stroke, and diabetes
GLP-1 medications work by targeting multiple pathways involved in weight regulation
This highlights the importance of antioxidants, such as glutathione, in potentially mitigating oxidative damage in the esophagus, although more research is needed to clarify its role