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50,51 Overall, SIRT1 functions as a key metabolic sensor and epigenetic regulator, with both expression and enzymatic activity finely tuned by internal and external cellular signals
Kidney In 2004, it was found that GLP-1 mediates effects on the kidney: Healthy and obese individuals treated with GLP-1 exhibited increased sodium excretion, glomerular filtration rate and urinary secretion
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