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But the strength of the evidence varies enormously according to the molecule, the formulation and the route of administration
This broad tissue distribution explains why GLP-1 RAs exert effects on multiple organ systems simultaneously, a property that makes them particularly suited to address the complex pathophysiology of NASH, which involves dysregulation of glucose and lipid metabolism, insulin resistance, inflammation, and fibrosis
Some experiments in murine systems have reported that supplementation may reverse certain transcriptional changes before they become irreversible, with indications that this could stabilize regulators such as PGC-1-alpha
doi:10.1007/s11064-016-1912-2 94
