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Who Should Avoid It Pregnancy and breastfeeding Concurrent MAOI use Stop Right Away If You Notice Serotonin syndrome signs Severe persistent headaches Cardiac symptoms Seizure activity Severe mood changes or suicidal ideation Milder Signs to Watch For How Long Should a PE-22-28 Cycle Last

Criteria for when a medication is to be administered (intermittently as needed or nightly), timing and dose escalation, as well as an exit strategy all need to be made explicit and agreed upon before initiation

Reduce temperature cycling by avoiding repeated warming and refreezing when possible to preserve integrity

Consequently, the skin becomes more resistant to environmental damage