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Morphological abnormalities such as mitochondrial swelling, cristae disruptions, and structural irregularities, coupled with reduced ATP levels and heightened ROS production, are observed in ovarian aging across various oocyte species, indicating compromised clearance processes [153, 291]
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Until that qualification work is done, the imaging and fluid measures are instruments for understanding the mechanism and selecting patients, while the question of whether these drugs modify the disease still belongs to the clinical endpoints
Mar 2004;87(3):255-263
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