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Available to buy in the UK from Peptides Lab UK, FOXO4-DRI is one of the most extensively studied senolytic research peptides in cellular senescence biology, with a rapidly growing published literature base spanning senescent fibroblast elimination, vascular ageing, Leydig cell senescence, chondrocyte biology, keloid scar research, cancer cell senescence, and structural NMR characterisation of the FOXO4p53 interaction
As multiple studies now show an impact of APOE on brain bioenergetics, which occurs prior to the onset of significant AD pathologies (Reiman et al., 1996), it is anticipated that improving our understanding of the L-carnitine system will help us better appreciate these early bioenergetics changes that could precede brain amyloid and tau pathologies and as such provide avenues for AD prevention
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Conflict of Interests The authors declare that they have no competing interests
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