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Stress Response & HPA Axis Regulation: Evaluating how the peptide modulates the endocrine response to physical and psychological stressors, particularly its influence on adrenocorticotropic hormone (ACTH) and cortisol secretion

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A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-

Finally, the in vivo efficacy of these small-molecule-derived HBs was demonstrated through transplantation into DMN-induced acute liver failure NSI mice