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As described in previous studies [28], this Comp score considered muscle strength and functional components, including the following four components: MM = muscle mass (kg), US = upper extremity strength by dynamometry (kg), LS = lower extremity strength by dynamometry (kg), 6W = 6-min walk test (meters)

[10] [11] [12] In the TMD domain a fulcrum of polar residues regulates the biased signaling of the receptor [10] while the transmembrane helical boundaries [13] and extracellular surface are a trigger for biased agonism

doi: 10.1016/j.bbadis.2021.166204 76 FarrsMRomnRCampsMMiretJMartnezPujolXet al