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Two separate human clinical trials have investigated this compound: Ulcerative Colitis Trial Clinical investigation of this compound in patients with ulcerative colitis examined the compounds GI-protective properties properties that are consistent with its gastric origin and documented activity on intestinal permeability barriers in animal models

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This variation has been associated with differences in serotonin transporter activity that may influence how efficiently serotonin is cleared from synapses after neurotransmission