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In contrast to the incretin hormones, where cleavage by DPP-4 results in a loss of their insulinotropic activity, cleavage of PYY results in altered receptor selectivity

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Semaglutide and orforglipron activate only the GLP-1 receptor, producing appetite suppression through hypothalamic signaling, delayed gastric emptying, and enhanced satiety

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Nearer-Term Availability# Recommendation : CagriSema Reason : NDA filed with FDA based on completed Phase 3 REDEFINE program

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