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Exenatide works more quickly but with similar benefits
Additionally, sex-specific effects remain underexplored, as evidence suggests differential susceptibility to Epstein-Barr virus-driven AD in females 25 , and metformin has been reported to exert sex-specific effects on cognition, which may interact with DM2 DMTs in influencing AD risk
Weight loss is a primary driver of downstream hormonal benefits, with semaglutide producing up to 15% body weight reduction over 68 weeks and a 2025 trial reporting a mean loss of 5.6 kg, compared with 2.3 kg with other treatments
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