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Phase 2 data reported nausea (~42%), vomiting (~20%), and diarrhoea (~18%) in the highest dose cohort, consistent with the GLP-1 class
Until now, the most effective GLP-1 weight loss treatments have mainly been weekly injections, which can put some patients off due to needle anxiety, inconvenience or stigma
The RD adopts the evolutionarily conserved Bateman module, consisting of two tandem CBS motifs (CBS-1 and CBS-2) and a surface-exposed loop (residues 516525) extending from a CBS-2 motif (Supplementary Fig
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