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Testing is particularly valuable for individuals with family histories that are incomplete or uncertain, those with thyroid nodules that have any features suggestive of MTC on biopsy, and anyone with personal or family history of pheochromocytoma or hyperparathyroidism (the other components of MEN 2)

According to the presence of immunohistochemistry markers, such as estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor 2 (HER2) molecular markers, breast cancer can be classified into three main subtypes: hormone receptor-positive (ER+, PR+, HER2), HER2 positive (ER, PR, HER2+), and triple-negative breast cancer TNBC (ER, PR, HER2)

Adv Healthc Mater 11(2):2101854

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