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Well, weight loss patients have five chief complaints: Tolerability - GLP-1s can induce GI side-effects, like nausea and vomiting Durability - once GLP-1 therapy is discontinued, patients regain weight Frequency - most GLP-1s are administered sub-cutaneously every week Access - Medicare, Medicaid, and most commercial insurers dont cover GLP-1s for weight loss
This decline is partly due to changes in the bodys ability to synthesize the amino acids required for glutathione production and increased oxidative stress with age
And the science is still evolving
10.1042/bst20230122 140 ZwebenJ
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