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A critic to the use of a murine model deficient for intestinal GCG products, would be that other gut hormones might compensate for the lack of a functional GCG gene in that tissue, hence explaining the normalized incretin effect
In response to demyelination in the adult brain, OPCs from dorsal origin are more strongly mobilized than ventral OPCs, but these cells are more sensitive to the age-related decline in differentiation potential (Crawford et al., 2016b)
Ideally, he adds, the use of MDI in individuals T2D should be restricted to those unable to achieve glycemic control with other pharmacological interventions
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