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Nonetheless, it should be used within a certain timeframe as recommended by the pharmacy (often 28 days after first puncture, per general guidelines for multi-dose vials, unless otherwise specified)

While these are population-level numbers, the principle applies to individuals as well: routine injection visits for non-deficient patients add up in copays, travel time, and appointment scheduling without delivering additional benefit

Lysyl oxidase: Copper is a required cofactor for lysyl oxidase, the enzyme that cross-links collagen and elastin fibers in the extracellular matrix

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