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She practices as an Internal Medicine Clinical Pharmacist at Robert Wood Johnson University Hospital in New Brunswick, New Jersey
has divulged incretin analogues acting as dual agonists of gastric inhibitory polypeptide (GIPR) receptor/GLP-1 or GLP-1/glucagon receptor (GCGR) or triple agonists of GIPR/GLP-1/GCGR reported to be useful for the treatment of type 2 diabetes, dyslipidemia, obesity, metabolic syndrome, neurodegeneration, fibrosis and cardiovascular disorders
These medicines work by mimicking a natural hormone that regulates blood sugar, slows digestion, and reduces appetite
The endogenous ligand GIP results in full agonism of the mouse GIPR, and the AMG 133 murine surrogate fully antagonized native GIP (IC 50 = 4.1 nM) (Extended Data Fig
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