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Effective transdermal drug delivery generally requires appropriate lipophilicity and molecular propertiesberberine's physicochemical characteristics are suboptimal for this route, primarily due to its ionic charge and poor lipid solubility
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In one clinical trial, PNS shows renoprotective effects on reducing albuminuria, proteinuria and Scr in patients with DKD (Tang et al., 2020)
Use no more than 120 ml (4 oz) of plain water - not sparkling, flavoured, or hot water
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