FDA has reported several shortages of GLP-1 formulations in its drug shortage database during 2023-2024
Symptoms requiring healthcare provider contact include: Rash or erythema spreading beyond the injection site or appearing at distant body locations Persistent or worsening symptoms lasting more than 4 to 5 days Significant pain that interferes with movement or daily function Development of pustules, blisters, or skin breakdown Warmth, increasing redness, or red streaking extending from the injection site (potential cellulitis) Fever, chills, or systemic symptoms accompanying local reactions Recurrent severe reactions at multiple injection sites Signs of possible allergic reaction, including hives, facial swelling, or difficulty breathing Call 911 or seek emergency care immediately for signs of severe allergic reaction such as difficulty breathing, throat tightness, severe dizziness, or widespread hives

But now the quest for randomized evidence of CVD benefits from treating obesity may soon yield dividends, thanks to two major multicenter trials of anti-obesity medications one run by the Cleveland Clinic Coordinating Center for Clinical Research (C5Research) and one with a Cleveland Clinic cardiologist as co-principal investigator
Participants We included all individuals aged 18 years and over who initiated either GLP-1RA or SGLT-2i treatment for type 2 diabetes from 1 January 2015 to 31 December 2021