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In vitro experiments showed that liraglutide could reduce the proliferation activity of CD4 + IFN- + T cells (Th1) and CD4 + IL-17a + T cells (Th17), but increase the number of CD4 + IL-4 + T cells (Th2) and CD4 + CD25 + T cells (Treg)
LDHA inhibition led to reduced lactate production, impaired aerobic glycolysis, decreased cell proliferation, and increased apoptosis in vitro , as well as significant tumor growth suppression in vivo (235)
Because the liver is the primary site of IGF-1 synthesis and a major organ of peptide metabolism, hepatic function directly shapes both the downstream effect of GH stimulation and the clearance of the drug itself
These combined effects make these medications effective for both blood sugar management and weight loss
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