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Apoptosis, the most common form of PCD, is particularly significant, as granulosa cells apoptosis deprives oocytes of the hormones and survival factors essential for their meiotic and developmental competence, which increases the susceptibility of oocytes to apoptotic factors, ultimately impairing ovarian reserve function
Sulfonylureas: a new class of cancer chemotherapeutic agents
However, this risk has not been demonstrated in humans at therapeutic doses, and the warning is being reevaluated based on post-marketing surveillance data
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