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GPR119 GPR119, also known among other names as glucose-dependent insulinotropic receptor (GDIR), was independently discovered less than two decades ago by several groups around the world and deorphanized soon after with the discovery of Oleoylethanolamide (OEA) as its first endogenous ligand (314316)
The SURMOUNT trial series showed that tirzepatide consistently outperformed semaglutide when both were studied head-to-head in similar patient populations
Given that compounded semaglutide is not FDA approved, prescribing guidelines may differ
PLoS ONE 9 , e111153 (2014)
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