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It is essential for tolerability and muscle preservation
These observations raise the possibility the ligand GLP-1(736) itself, by increasing intracellular cAMP, exerts a stimulatory rather than an inhibitory effect on glucagon secretion [57]
What to Do: Discuss alternative contraceptive methods such as an IUD or patch with the doctor who prescribed your birth control Consider additional protection , especially in the early phase of GLP-1 therapy, such as barrier protection (condoms) Avoid sex during ovulation , thereby reducing the risk of pregnancy 2
Importantly, the gastric emptying delay tends to attenuate with continued therapy (tachyphylaxis), which may explain why some gastrointestinal effects improve over time
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