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First approved as the iPLEDGE Program in 2005, then as the iPLEDGE REMS (Risk Evaluation and Mitigation Strategy) in 2010, it established a centralized system for prescribers, pharmacies, and patients to manage patient risk, regardless of which isotretinoin product is being used
These changes reduce its binding affinity to IGF-binding proteins (IGFBPs), allowing for a longer half-life (up to 2030 hours) and increased bioavailability in plasma
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Topical peptide serums sold over the counter are not equivalent to injectable clinical protocols
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