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Severe pain initially, then decreased due to nerve damage
The hypothalamus, located above the midbrain, plays a central role in integrating signals regarding food intake, energy balance, and body weight
Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization
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