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Tirzepatide may be appropriate for adults who meet certain criteria: For weight loss (Zepbound): BMI of 30 or greater, or BMI of 27 or greater with at least one weight-related comorbidity such as hypertension, dyslipidemia, or obstructive sleep apnea For type 2 diabetes (Mounjaro): As an adjunct to diet and exercise for glycemic control Candidates should be prepared to commit to ongoing lifestyle changes including nutrition, physical activity, and regular medical follow-up as part of a structured medical weight loss approach
The processing workflow for the cryo-EM structures are summarised in Supplementary Fig
