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422 Some studies also showed that HER2 heterogeneity correlated with worse clinical outcomes, 423 and HER2 intra-tumoral heterogeneity could be another potential factor for the resistance to anti-HER2 therapy
Biochemistry 37 , 1323913249 (1998)
BresellA.WeinanderR.LundqvistG.RazaH.ShimojiM.SunT
As stopped-flow analysis measures the overall change in protein fluorescence, and considering the kinetic allostery implied in the steady-state kinetics, it is possible to conclude that the rate limitation is related to structural changes
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