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When skin is calm, KPV may not solve an active bottleneck

NSAIDs, like ibuprofen, for instance, cannot be used for long periods of time because they increase gastric bleeding as well as the risk for heart attack

D.AndersD.et al (2007)

Furthermore, the concomitant rate of auto-oxidation of doxorubicin within the cell is assumed to be equal to that of the OCR experimental data used to parameterise the model