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When the integrity of the BBB is breached, infiltrating blood components and immune cells activate perivascular glia, igniting an inflammatory cascade that accelerates neuronal damage
Human dosing, long-term safety, and drug interactions are not established
In rams, 0.3 mM -Tocopherol significantly improves post-thaw motility, viability, normal sperm percentage, and functional integrity, while low-dose vitamin C (0.1 mM) also enhances sperm quality but leads to more secondary abnormalities (87)
Science 388 , eadk3487 (2025)
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