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They stimulate insulin secretion and inhibit glucagon secretion by elevating endogenous GLP-1 concentrations without an intrinsic hypoglycaemia risk
Semaglutide must be discontinued if pregnancy occurs or at least 2 months before a planned pregnancy
10.1038/nn.2536 96 JagielskaA.LoweA
To put this transformation in perspective, consider that over 80% of adults with type 2 diabetes in the United States meet the criteria for GLP-1 receptor agonists or SGLT2 inhibitors, though only one in 10 people used either medication from 2017 to 2020
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