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The threshold concentration for tubular reabsorption (above which the fractional reabsorption begins to decline) is about 4060 mol/L, which is similar to the endogenous plasma L-carnitine level

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The current hypothesis is that because adequate concentrations of GSH are required for proper lymphocyte function, a deficiency in GSH may contribute to the immunodeficiency seen in the later stages of HIV infection

Our study indicates that SAC interferes with the interaction between Keap1 and Nrf2, stabilizing Nrf2 and promoting its accumulation in the nucleus, thereby activating the expression of downstream antioxidant genes such as NQO1 and GPX4