flow trial semaglutide results versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials Semaglutide in patients with overweight

Clinical trials show weight loss averaging 15-17% of body weight over a year

And if you've got side effects that are a rate of one in a million, then randomised trials will not necessarily pick those up, particularly if what they've done, which is what they did do in some of these trials, of these GLP-1 agonists, is that they didn't allow people who had mental health issues or who are on antidepressants onto the trials

Effect of sodium-glucose cotransporter 2 inhibitors on weight reduction in overweight and obese populations without diabetes: a systematic review and a meta-analysis

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