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The ability of MEDI4166 to improve glycaemic control in a model of Type 2 diabetes was investigated in male db/db mice following weekly injections of MEDI4166 at 3, 10 or 30 mg/kg over a 4 weeks period
Specifically, we found the aromatic SNAC/SNAC NOE coupling intensities to be sensitive to the increasing SNAC concentration, suggesting that SNAC aggregates in the CTAB micelle environment, likely via a combination of -stacking between the aromatic SNAC residues and hydrogen bonding interactions
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