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and (4) coarse precipitates of denatured hemoglobin cause irreversible damage to the membrane, and the red blood cells lyse or become prey to macrophages

There are several main causes of pinched nerves: Nerves can get pinched in the neck as a result of injured discs, such as disc bulges, protrusion, herniation, or disc annular tears

Glossary AChE Acetylcholinesterase AMPK adenosine 5-monophosphate-activated protein kinase CAT catalase CCL2 chemokine ligand 2 CeO2 cerium oxide CP cisplatin Ctr1/2 copper transporters 1/2 CUR curcumin DA 3,4-dihydroxybenzoic acid DMF dimethyl fumarate DRG dorsal root ganglia EFSF extract of Forsythiae suspensa fruits EFVF extracts of Forsythia viridissima fruits FA folic acid GFAP glial fibrillary acidic protein GJG goshajinkigan GPx glutathione peroxidase GST glutathione-S-transferase HCC hepatocellular carcinoma HGWD Guizhi Wuwu decoction HSYA hydroxysafflor yellow A IDO-1 indoleamine 2,3-dioxygenase 1 IENFs intraepidermal nerve fibers IL-1 interleukin-1 IL-6 interleukin-6 iNOS inducible nitric oxide synthase JHGWD Jiawei Huangqi Guizhi Wuwu decoction MATE multidrug and toxin extrusion proteins MBP myelination MDA molondialdehyde Mg magnesium MMF metabolite monomethyl fumarate MNCV motor nerve conduction velocity MnSOD manganese superoxide dismutase MPZ myelin protein zero MSC mesenchymal stem/stromal cells MSNs mesoporous silica nanoparticles MTD maximum tolerated dose NF-B nuclear factor kappa-B Nrf2 NF-E2-related factor 2 NPs nanoparticles OCTs organic cation transporter OXA oxaliplatin PAA poly (acrylic acid) PIPN platinum-induced peripheral neuropathy PPa photosensitizer pheophorbide A Pt platinum ROS reactive oxygen species RyR ryanodine receptor SNCV sense nerve conduction velocity SOD superoxide dismutase TGF- transforming growth factor- TNFR1 necrosis factor receptor 1 TNF- tumor necrosis factor TRP transient receptor potentials TRPA1 transient receptor potential ankyrin 1 TRPM8 transient receptor potential melastatin 8 References 1 AbdelhamidA

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