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Chagnon-Choquet, J
The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017)
Tissue samples were examined for macroscopic damage assessed by a single observer (M.S.) blinded to characteristics or treatment of the animal being studied, according to previously described criteria (Mourelle et al, 1996) that takes into account (1) presence of adhesions (score 02), (2) strictures (score 03), (3) ulcers (score 03), and (4) wall thickness (score 02)
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