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Practical implication: 503A pharmacies can compound semaglutide for individual patients with documented clinical justification (allergy to commercial product excipients, non-standard dose, or documented medical necessity for combination formulation), but cannot operate at the industrial scale that characterized 2022-2024 telehealth compounding
Reconstitution Math (5 mg vial, 3 mL BAC water) Dose 100 mcg Concentration ~1,667 mcg/mL Dose volume 0.06 mL U-100 units 6 units Dose 200 mcg Concentration ~1,667 mcg/mL Dose volume 0.12 mL U-100 units 12 units Dose 300 mcg Concentration ~1,667 mcg/mL Dose volume 0.18 mL U-100 units 18 units This assumes 5 mg total peptide divided by 3 mL BAC water
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