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That is the reason it is considered relatively safe even at high doses
Hospital Pharmacy , 48 (4), 282301
Phase 1 corresponds to a high level of activity in the primary afferent as a result of C-fiber activation due to peripheral stimulation, whereas phase 2 results from a continuous low-level small afferent input, together with a facilitated state of spinal processing [21]
doi: 10.1016/j.cyto.2018.09.008 181 NtougkosEChouvardasPRoumeliotiFOspeltCFrank-BertonceljMFilerAet al
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