what was the first glp 1 Wegovy Pill Wins FDA Approval as GLP-1 Oral Treatment for Obesity and Weight Loss Evolution of GLP‐1 Receptor Agonists

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"By adding PYY to the GLP1/GIP/glucagon trio, we hope to rely less on GLP1 and glucagon to drive weight loss, potentially lowering the chance of nausea (from GLP1/PYY) and high blood sugar risk (from glucagon) while keeping the benefits." The medication is still in the experimental/preclinical stage and has not yet been tested in human trials

Nat Rev Mol Cell Biol (2012) 13:61630

Due to the lack of major changes in ELF GSH with longer exposures, it stands to reason that the GSH adaptive response was established early, within 1 day, and then maintained for extended periods of time