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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771
The strongest human evidence is topical
5-Amino-1MQ is available only through licensed medical providers
The enzyme catalyzes the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl-L-methionine (SAM) as a cofactor, producing 1-methylnicotinamide (1-MNA) as a metabolic byproduct
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