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[15] For licensed GLP-1 receptor agonists, the Yellow Card scheme has contributed to the pharmacovigilance process that informed the EMA PRAC 2024 review and MHRA communications on psychiatric safety signals across this drug class

Newer dual-agonist medications like tirzepatide (Zepbound) have shown even more dramatic results, with some trial participants losing more than 20% of their body weight over the course of treatment

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