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This process is particularly important within the liver, where glutathione contributes to Phase II detoxification pathways and helps protect cells from oxidative injury during normal metabolic activity
Inflammatory factors (e.g., TNF-, IL-6) and ROS associated with IBD impair the capacity of cells to repair lipid peroxidation by inhibiting the activity or expression of GPX4, synergizing with iron overload to significantly lower the threshold for epithelial cells to undergo ferroptosis
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& Kopito, R
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