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More significant changes to established dark spots or melasma typically take eight to twelve weeks

Key considerations include the range of available medications, insurance acceptance, and the level of clinical support

The sites, which appear to be operating beyond the purview of the Food and Drug Administration and against social media community standards to boot often warn that their wares are not for human consumption and sold only for research purposes. But at the same time, the WSJ points out, they often provide instructions for human dosages, giving the whole thing a wink-wink vibe

Laboratory safety protocols require researchers to handle Reta with appropriate personal protective equipment, including gloves, laboratory coats and protective eyewear