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Coverage Considerations Saxenda: Longer FDA approval history (2014) may mean better coverage on some plans Step therapy: Some plans require trying Saxenda before approving Zepbound Zepbound: Superior efficacy (20.9% vs ~8% weight loss) may justify coverage even if more expensive Cash Pay Options If insurance doesn't cover your preferred option: Zepbound via LillyDirect: $299$449/month (vials, Dec 2025) Saxenda: ~$1,400/month retail
Prasad S et al
Annual cost: $14,400
It can be taken more easily and behaves more like a typical oral drug
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