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CHEST 2017

Van Dorpe S, Bronselaer A, Nielandt J et al (2012) Brainpeps: the blood-brain barrier peptide database

Treatment of central nervous system (CNS) relapse in adult acute lymphoblastic leukemia (ALL)

The authors proposed the following model of Se uptake to the brain via SELENOP-LRP8: SELENOP present in blood and CSF is taken up by LRP8-positive cells of BBB and BCB, resynthesized in neighboring astrocytes, and subsequently released to supply LRP8-positive neurons within the brain with Se Figure 2