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( Peptide InnOvatioN for the Early diabetEs tReatment (PIONEER) trial showed that GLP-1RAs caused an overall nausea rate of 15-20% and were associated with gastrointestinal adverse events, but these were temporary and dose-dependent ( Underlying mechanism The mechanisms that contribute to the beneficial effects of SGLT2i and GLP-1RAs in patients with T2DM have been extensively studied
Specifically, the enhanced anxiolytic effects seen with DSIP-CBBBP treatment compared to DSIP alone likely arise from the synergistic role of CBBBP and DSIP
After that date, it may still be safe and effective, but there is not enough evidence to support beyond that timeframe
Whatever the schedule, remodeling continues for weeks, so results are judged over a multi-week to multi-month horizon, not immediately
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